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成功大學 生命科學系

​彭怡禎  副教授

辦公室電話: +886-6-275-7575 ext. 58123

email: ipeng@mail.ncku.edu.tw

學歷：

博士  生物化學與分子生物學所，美國加州大學河濱分校

碩士  微生物學組，農業化學所，國立臺灣大學

學士  農業化學系，國立臺灣大學

經歷：

2020-              副教授， 國立成功大學生命科學系

2014-2020年  助理教授， 國立成功大學生命科學系

2012-2014年  博士後研究員，美國紐約石溪大學

2011-2012年  博士後研究員，美國加州大學河濱分校

A. 期刊論文

  1. Jin-Wei Jhu, Jia-Bao Yan, Zou-Han Lin, Shih-Chieh Lin, and I-Chen Peng*. (2021). SREBP1-induced glutamine synthetase triggers a feedforward loop to upregulate SREBP1 through Sp1 O-GlcNAcylation and augments lipid droplet formation in cancer cells. International Journal of Molecular Sciences. 22(18), 9814.

  2. Jia-Bao Yan, Chien-Cheng Lai, Jin-Wei Jhu, Brendan Gongol, Traci L. Marin, Shih-Chieh Lin, Hsiang-Yi Chiu, Chia-Jui Yen, Liang-Yi Wang, and I-Chen Peng*. (2020). Insulin and metformin control cell proliferation by regulating TDG-mediated DNA demethylation in liver and breast cancer cells. Molecular Therapy-Oncolytics. 18: 282-294. 

  3. Pai-Sheng Chen, Wen-Tai Chiu, Pei-Ling Hsu , Shih-Chieh Lin , I-Chen Peng, Chia-Yih Wang , Shaw-Jenq Tsai. (2020). Pathophysiological implications of hypoxia in human diseases. Journal of Biomedical Science. 27(1):63.

  4. I-Chen Peng*, Alex J. Bott, and Wei-Xing Zong*. (2016). Spectrophotometric determination of glutamine synthetase activity in cultured cells. Bio-protocol 6(19): e1959. (* For correspondence)

  5. Alex J. Bott, I-Chen Peng (co-first author), Yongjun Fan, Brandon Faubert, Lu Zhao, Jinyu Li, Sarah Neidler, Yu Sun, Nadia Jaber, Dawid Krokowski, Wenyun Lu, Ji-An Pan, Scott Powers, Joshua Rabinowitz, Maria Hatzoglou, Daniel J. Murphy, Russell Jones, Song Wu, Geoffrey Girnun, and Wei-Xing Zong. (2015). Oncogenic Myc induces expression of glutamine synthetase through promoter demethylation. Cell Metabolism. 22(6):1068-1077.

  6. Yu-Ting Hung, Chi-Te Liu, I-Chen Peng, Chin Hsu, Roch-Chui Yu, Kuan-Chen Cheng. (2015). The implementation of a Hazard Analysis and Critical Control Point management system in a peanut butter ice cream plant. J Food Drug Anal. 23(3):509-515.

  7. Brendan Gongol, Traci Marin, I-Chen Peng, Brian Woo, Stephanie King, Marcy Martin, Wei Sun, Shu Chien, and John Y-J. Shyy. (2013). AMPKa2 exerts its anti-inflammatory effects through PARP-1 and Bcl-6. Proc Natl Acad Sci U S A. 110(8):3161-3166.

  8. I-Chen Peng, Kai-Yin Lo, Chun-Hua Hsu, and Chia-Yin Lee. (2012). Increasing the storage and oxidation stabilities of N-acyl-D-amino acid amidohydrolase by site-directed mutagenesis of critical methionine residues. Process Biochemistry. 47:1785-1790.

  9. I-Chen Peng, Zhen Chen, Wei Sun, Ying-Shiuan Li, Traci LaNai Marin, Pang-Hung Hsu, Mei-I Su, Xiaopei Cui, Songqin Pan, Christian Y. Lytle, David A. Johnson, Frank Blaeser, Talal Chatila, and John Y-J. Shyy. (2012). Glucagon regulates ACC activity in adipocytes through the CaMKKb/AMPK pathway. Am J Physiol Endocrinol Metab. 302(12):E1560-1568.

  10. Zhen Chen, I-Chen Peng (co-first author), Xiaopei Cui, Yi-Shuan Li, Shu Chien, and John Y-J. Shyy. (2010). Shear stress, SIRT1, and vascular homeostasis. Proc Natl Acad Sci U S A. 107(22):10268-10273.

  11. Zhen Chen, I-Chen Peng, Wei Sun, Mei-I Su, Pang-Hung Hsu, Yi Fu, Yi Zhu, Kathryn DeFea, Songqin Pan, Ming-Daw Tsai, and John Y-J. Shyy. (2009). AMP-activated protein kinase functionally phosphorylates endothelial nitric oxide synthase Ser633. Circ Res. 104:496-505.

B. 研討會論文

  1. I-Chen Peng. “Myc induces expression of glutamine synthetase through promoter demethylation.” The 5th International Conference and Exihibition on Metabolomics 2016, Osaka, Japan. (Invited Speaker)

  2. I-Chen Peng, Alex J. Bott, Yongjun Fan, Brandon Faubert, Lu Zhao, Jinyu Li, Sarah Neidler, Yu Sun, Nadia Jaber, Dawid Krokud, Maria Hatzoglou, Scott Powers, Daniel J. Murphy, Russell Jones, Song Wu, Geoffrey Girnun, and Wei-Xing Zong. “Myc induces expression of glutamine synthetase through thymine DNA glycosylase-mediated promoter demethylation.” The 15th SCBA International Symposium 2015, Academia Sinica, Taipei, Taiwan.

  3. I-Chen Peng, Alex J. Bott, Yongjun Fan, Brandon Faubert, Lu Zhao, Jinyu Li, Sarah Neidler, Yu Sun, Nadia Jaber, Dawid Krokud, Maria Hatzoglou, Scott Powers, Daniel J. Murphy, Russell Jones, Song Wu, Geoffrey Girnun, and Wei-Xing Zong. “Myc induces expression of glutamine synthetase through thymine DNA glycosylase-mediated promoter demethylation.”The 8th France-Taiwan Frontiers of Science 2015, Kaohsiung, Taiwan

  4. I-Chen Peng, Alex Bott, Yongjun Fan, Nadia Jaber, and Wei-Xing Zong. “c-Myc Induces Expression of Glutamine Synthetase through DNA demethylation.” Gloria and Mark Snyder Symposium for Cancer Medicine 2014, Stony Brook, New York, USA.

  5. I-Chen Peng, Alex Bott, Yongjun Fan, Nadia Jaber, and Wei-Xing Zong. “c-Myc Induces Expression of Glutamine Synthetase through DNA demethylation.” Molecular Genetics and Microbiology Annual Department Retreat 2013, Port Jefferson, New York, USA.

  6. I-Chen Peng, Zhen Chen, Pang-Hung Hsu, Mei-I Su, Ming-Daw Tsai, and John Y-J. Shyy. “Glucagon Activates the AMP-Activated Protein Kinase/Acetyl-CoA Carboxylase Pathway in Adipocytes.” Experimental Biology Meeting 2010, Anaheim, California, USA.

  7. I-Chen Peng and John Y-J. Shyy. “AMP-Activated Protein Kinase Phosphorylates Acetyl-CoA Carboxylase at Ser-79 Responding to Glucagon.” 21st Annual Biochemistry and Molecular Biology Research Symposium 2009, Riverside, California, USA.

  8. Zhen Chen, I-Chen Peng, Wei Sun, Mei-I Su, Pang-Hung Hsu, Songqin Pan, Ming-Daw Tsai, and John Y-J. Shyy. “Shear Stress Increases the Phosphorylation of eNOS Ser-633 and Level of Sirt1.” The 12th SCBA International Symposium 2009, Academia Sinica, Taipei, Taiwan.

教授科目: 

大學部課程 : 生物化學、代謝生化學、細胞生物學、營養學、營養基因體學、動物生理學、普通生物學、普通生物學實驗、生命科學概論、書報討論

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研究所課程 : 分子醫學特論、細胞動力學、高等細胞生物學、專題討論

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